Dr. Lars Lewejohann
I
studied Biology and Philosophy at the University of
Muenster and finished my diploma thesis in 1999. Subject of the diploma
thesis was the
evaluation of housing conditions of laboratory mice from an animals'
point of view using
preference tests. In brief: If mice have the choice, they prefer
enriched housing
conditions and will even work (pressing a lever up to 16 times per
entry) for the access
to a more entertaining housing system.
In my
PhD-project "Behavioral Phenotyping of Mice: Methods,
Evaluation, and Appliance" I investigated BC1-RNA knockout mice by
means of a battery of behavioral
tests. Tests were carried out with different knockout lines in
different laboratories. The combined results indicate that although BC1
RNA does not code any protein, it seems to be involved in the
modulation of explorative behavior. Since 2004 I am working as a
research assistant in the Department of Behavioural Biology of the University of
Muenster.
From 2006 to 2010 I was additionally working as the managing director of
the Otto
Creutzfeldt Center for Cognitive and Behavioral Neuroscience (OCC), an
association for research and education spanning different faculties of the
University of Muenster focusing on behavioral neuroscience.
Publications (including
publications in popular press)
-
Hundelt, M; Fath, T; Selle, K; Oesterwind, K; Jordan, J; Schultz, C; Götz, J; von Engelhardt, J;
Monyer, H; Lewejohann, L; Sachser, N; Bakota, L; Brandt, R (in press): Altered phosphorylation
but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiology of Aging.
- Richter, SH; Garner, JP; Zipser, B; Lewejohann, L; Sachser, N; Touma, C; Schindler, B; Chourbaji, S; Brandwein, C; Gass, P; van Stipdonk, N; van der Harst, J; Spruijt, B; Voikar, V; Wolfer, DP; Würbel, H (2011): Effect of population heterogenization on the reproducibility of mouse behavior: a multi-laboratory study. PLoS one 6: e16461.
-
Lewejohann, L; Kloke, V; Heiming, RS; Jansen, F; Kaiser, S; Schmitt, A; Lesch, KP; Sachser, N (2010): Social status and day-to-day behaviour of male serotonin transporter knockout mice. Behavioural Brain Research.
-
Jansen, F; Heiming, RS; Lewejohann, L; Touma, C; Palme, R; Schmitt, A; Lesch, KP; Sachser, N (2010): Modulation of Behavioural Profile and Stress Response by 5-HTT Genotype and Social Experience in Adulthood. Behavioural Brain Research 207: 21-29.
-
Diederich, K; Sevimli, S; Dörr, H; Kösters, E; Hoppen, M; Lewejohann, L; Klocke, R; Minnerup, J; Knecht, S; Nikol, S; Sachser, N; Schneider, A; Gorji, A; Sommer, C; Schäbitz, WR (2009): The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: A characterization of G-CSF deficient mice. The Journal of Neuroscience 29: 11672-11581.
- Ambrée, O; Richter, H; Sachser, N; Lewejohann, L; Dere, E;
de Souza Silva, MA; Herring, A; Keyvani, K; Paulus, W; Schäbitz, WR (2009):
Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer's
disease. Neurobiology of Aging. 1192-1204.
-
Heiming, RS; Jansen, F; Lewejohann, L; Kaiser, S; Schmitt, A; Lesch, KP; Sachser, N (2009): Living in a dangerous world: the shaping of behavioral profile by early environment and 5-HTT genotype. Frontiers in Behavioral Neuroscience 3: 26.
-
Lewejohann, L; Damm, OS; Luetjens, CM; Hämäläinen, T; Simoni, M; Nieschlag, E; Gromoll, J; Wistuba, J (2009): Impaired recognition memory in male mice with a supernumerary X chromosome. Physiology & Behavior 96: 22-29.
-
Lewejohann, L; Hoppmann, AM; Kegel, P; Kritzler, M; Krüger, T; Sachser, N (2009): Behavioral phenotyping of a murine model of Alzheimer's disease in a semi-naturalistic environment using RFID tracking. Behavior Research Methods 41: 850-856.
-
Lewejohann, L; Reefmann, N; Widmann, P; Ambrée, O; Herring, A; Keyvani, K; Paulus, W; Sachser, N (2009): Transgenic Alzheimer mice in a semi-naturalistic environment: More plaques, yet not compromised in daily life. Behavioural Brain Research 201: 99-102.
- Bacher, M; Dodel, R; Aljabari, B; Keyvani, K; Marambaud, P; Kayed, R; Glabe, C; Görtz, N; Hoppmann, A; Sachser, N; Klotsche, J; Schnell, S; Lewejohann, L; Al-Abed, Y (2008): CNI-1493 inhibits Aß production, plaque formation, and cognitive deterioration in an aimal model of Alzheimer’s disease. The Journal of Experimental Medicine 205 (7): 1593-1599.
- Görtz, N; Lewejohann, L; Tomm, M; Ambrée, O; Keyvani, K; Paulus, W; Sachser, N (2008): Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice. Behavioural Brain Research 191: 43-48.
- Kritzler, M; Lewejohann, L; Krüger (2007): Analysing Movement and Behavioural Patterns of Laboratory Mice in a Semi Natural Environment Based on Data collected via RFID-Technology. In: Gottfried, B (ed.): Workshop on Behaviour Monitoring and Interpretation. Osnabrück.
- Kritzler, M; Lewejohann, L; Krüger, A; Raubal, M; Sachser, N (2006): An RFID-based tracking system for laboratory mice in a semi-natural environment. In: A. Schmidt, S. Spiekermann, A. Gershman, F. Michahelles (ed.): PTA2006 Workshop, PERVASIVE - pervasive technology applied real-world experiences with RFID and sensor networks. Dublin, Ireland.
-
Lewejohann, L; Reinhard, C; Schrewe, A; Brandewiede, J; Haemisch, A; Görtz, N; Schachner, M; Sachser, N (2006):
Environmental Bias? Effects of Housing Conditions, Laboratory Environment, and Experimenter on
Behavioral Tests. Genes Brain and Behavior 5: 64-72.
- Ambrée, O.; Görtz, N.; Keyvani, K.; Lewejohann,
L.;
Palme, R.; Paulus, W.; Touma, C.; Sachser, N. (2005): Early behavioural
and hormonal alterations in TgCRND8 Alzheimer mice. In: Hossmann, K.-A.
(ed.): Neuro-Visonen 2: Perspektiven in NRW. Verlag Ferdinand
Schöningh, Paderborn: 194-195.
- Lewejohann,
L; Skryabin, BV; Sachser, N; Prehn, C; Heiduschka, P; Thanos, S;
Jordan, U; Dell'Omo, G; Vyssotski, AL; Pleskacheva, MG; Lipp, HP;
Tiedge, H; Brosius, J; Prior, H (2004): Role of a neuronal small
non-messenger RNA: behavioural alterations in BC1 RNA-deleted mice.
Behavioural Brain Research 154: 273-289.
- Touma, C; Ambrée, O; Görtz, N; Isenberg, S; Keyvani,
K; Lewejohann,
L; Palme, R; Paulus, W; Schwarze-Eicker, K; Sachser, N (2004):
Behavioral and endocrine alterations in a mouse model of Alzheimer's
disease: early indicators of neuropathological changes? Hormones and
Behaviour 46: 103.
- Touma, C; Ambrée, O; Görtz, N; Keyvani, K; Lewejohann,
L; Palme, R; Paulus, W; Schwarze-Eicker, K; Sachser, N (2004): Age- and
sex-dependent development of adrenocortical hyperactivity in a
transgenic mouse model of Alzheimer's disease. Neurobiology of Aging
25: 893-904.
- Sachser, N; Ambrée, O; Görtz, N; Keyvani, K; Lewejohann,
L; Palme, R; Paulus, W; Touma, C (2003): Behavioral and endocrinologic
characterization of a transgenic mouse model of the Alzheimer disease.
Hormones and Behavior 44: 73-74.
- Böckels, C; Lewejohann, L; Sachser, N (2002):
Applying
elo-rating to assess dominance hierarchiy in male mice. Zoology 105,
Supplement V (DZG 95.1): 3.
- Lewejohann, L; Prior, H; Brosius, J; Sachser, N;
Skryabin, BV (2002): Behavioural phenotyping of mice lacking BC1, a
non-protein coding gene. Zoology 105, Supplement V (DZG 95.1): 3.
- Lewejohann, L (2001): Was für ein Haus will die Maus?
Rodentia 1: 73-75.
- Lewejohann, L; Edich, I; Sachser, N (2001): Rhythm of
activity in closely related inbred strains of mice. Contributions to
the XXVII International Ethological Conference, Tübingen, Advances
in
Ethology 36. Supplements to Ethology: 204.
- Lewejohann, L; Edich, I; Sachser, N (2001): Circadian
rhythm of three closely related inbred strains of mice differing in
aggressive behaviour. Zoology 104, Supplement IV (DZG 94.1): 7.
- Lewejohann, L; Sachser, N (2000): Evaluation of
different housing conditions for male laboratory mice. Zoology 103,
Supplement III (DZG 93.1): 31.
- Lewejohann, L; Sachser, N (2000): Präferenztests zur
Beurteilung unterschiedlicher Haltungsbedingungen von männlichen
Labormäusen. In: Aktuelle Arbeiten zur artgemäßen
Tierhaltung 1999.
KTBL Schrift 391. Darmstadt: 170-177.
- Lewejohann, L; Wistuba, J (1999): Mimicry, disappearing
acts and imposters. Reptilia (GB) 8: 70-75.
- Lewejohann, L; Wistuba, J (1997): Guck mal wer da rasselt
- 'Geräuschmimikry' bei Schlangen. Reptilia 6: 28-29.
- Lewejohann, L; Wistuba, J (1997): Mimikry - Tarnkappen und
Hochstapler. Reptilia 6: 16-21.
Memberships
Association
for the Study of Animal Behaviour
Deutsche
Zoologische Gesellschaft e.V.
Ethologische
Gesellschaft e.V.
The
International
Behavioural and Neural Genetics Society
Universities Federation for Animal Welfare (UFAW)
Scientific Board
Rodentia
- Kleinsäuger Fachmagazin